Structure of PDB 2wca Chain A

Receptor sequence
>2wcaA (length=578) Species: 226186 (Bacteroides thetaiotaomicron VPI-5482) [Search protein sequence]
LQPPPQQLIVQNKTIDLPAVYQLNGGEEANPHAVKVLKELLSGMLISIGE
KGDKSVRKYSRQIPDHKEGYYLSVNEKEIVLAGNDERGTYYALQTFAQLL
KDGKLPEVEIKDYPSVRYRGVVEGFYGTPWSHQARLSQLKFYGKNKMNTY
IYGPKDDPYHSAPNWRLPYPDKEAAQLQELVAVANENEVDFVWAIHPGQD
IKWNKEDRDLLLAKFEKMYQLGVRSFAVFFDDISGEGTNPQKQAELLNYI
DEKFAQVKPDINQLVMCPTEYNKSWSNPNGNYLTTLGDKLNPSIQIMWTG
DRVISDITRDGISWINERIKRPAYIWWNFPVSDYVRDHLLLGPVYGNDTT
IAKEMSGFVTNPMEHAESSKIAIYSVASYAWNPAKYDTWQTWKDAIRTIL
PSAAEELECFAMHNSDLGPNGHGYRREESMDIQPAAERFLKAFKEGKNYD
KADFETLQYTFERMKESADILLMNTENKPLIVEITPWVHQFKLTAEMGEE
VLKMVEGRNESYFLRKYNHVKALQQQMFYIDQTSNQNPYQPGVKTATRVI
KPLIDRTFATVVKFFNQKFNAHLDATTD
3D structure
PDB2wca Insight Into a Strategy for Attenuating Ampc- Mediated Beta-Lactam Resistance: Structural Basis for Selective Inhibition of the Glycoside Hydrolase Nagz.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.169: protein O-GlcNAcase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NP6 A G135 Y282 W286 T310 V314 W337 N339 D344 Y345 H433 G124 Y271 W275 T299 V303 W326 N328 D333 Y334 H422 PDBbind-CN: -logKd/Ki=5.60,Ki=2.5uM
BS02 CA A E32 E61 D64 E28 E50 D53
Gene Ontology
Molecular Function
GO:0015929 hexosaminidase activity
GO:0016231 beta-N-acetylglucosaminidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0042802 identical protein binding
GO:0102571 [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006517 protein deglycosylation
GO:1901135 carbohydrate derivative metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2wca, PDBe:2wca, PDBj:2wca
PDBsum2wca
PubMed19499593
UniProtQ89ZI2|OGA_BACTN O-GlcNAcase BT_4395 (Gene Name=BT_4395)

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