Structure of PDB 2wb4 Chain A

Receptor sequence
>2wb4A (length=458) Species: 190650 (Caulobacter vibrioides CB15) [Search protein sequence]
SARILVVDDIEANVRLLEAKLTAEYYEVSTAMDGPTALAMAARDLPDIIL
LDVMMPGMDGFTVCRKLKDDPTTRHIPVVLITALDGRGDRIQGLESGASD
FLTKPIDDVMLFARVRSLTRFKLVIDELRQREASGRRMGVIAGAAARLDG
LGGRVLIVDDNERQAQRVAAELGVEHRPVIESDPEKAKISAGGPVDLVIV
NAAAKNFDGLRFTAALRSEERTRQLPVLAMVDPDDRGRMVKALEIGVNDI
LSRPIDPQELSARVKTQIQRKRYTDYLRNNLDHSLELAVTDQLTGLHNRR
YMTGQLDSLVKRATLGGDPVSALLIDIDFFKKINDTFGHDIGDEVLREFA
LRLASNVRAIDLPCRYGGEEFVVIMPDTALADALRIAERIRMHVSGSPFT
VAHGREMLNVTISIGVSATAGEGDTPEALLKRADEGVYQAKASGRNAVVG
KAAHHHHH
3D structure
PDB2wb4 Crystal Structure of Activated Pled, Identification of Dimerization and Catalysis Relevant Regulatory Mechanisms
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.65: diguanylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BEF A D53 V54 M55 T83 A84 K105 D52 V53 M54 T82 A83 K104
BS02 MG A D10 D53 M55 D9 D52 M54
BS03 C2E A R359 D362 D383 I387 R390 R358 D361 D382 I386 R389
BS04 C2E A N357 R359 R390 N356 R358 R389
BS05 C2E A R313 L316 R312 L315
BS06 C2E A P72 R137 G144 A145 A146 P71 R136 G143 A144 A145
Gene Ontology
Molecular Function
GO:0005525 GTP binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0052621 diguanylate cyclase activity
Biological Process
GO:0000160 phosphorelay signal transduction system
GO:0030154 cell differentiation
GO:0043709 cell adhesion involved in single-species biofilm formation
GO:1902201 negative regulation of bacterial-type flagellum-dependent cell motility
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2wb4, PDBe:2wb4, PDBj:2wb4
PDBsum2wb4
PubMed
UniProtB8GZM2|PLED_CAUVN Response regulator PleD (Gene Name=pleD)

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