Structure of PDB 2wa7 Chain A

Receptor sequence
>2wa7A (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]
APWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKR
MYRKYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLIL
GLVWTLILHYSISMPVWEDEGKKQTPKQRLLGWIQNKIPYLPITNFNQNW
QDGKALGALVDSCAPGLCPDWESWDPQKPVDNAREAVQQADDWLGVPQVI
TPEEIIHPDVDEHSVMTYLSQFPKA
3D structure
PDB2wa7 Disease-Associated Substitutions in the Filamin B Actin Binding Domain Confer Enhanced Actin Binding Affinity in the Absence of Major Structural Disturbance: Insights from the Crystal Structures of Filamin B Actin Binding Domains.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO3 A W189 E200 W174 E185
BS02 CO3 A E129 W148 P238 E118 W133 P223
Gene Ontology
Molecular Function
GO:0051015 actin filament binding
Biological Process
GO:0030036 actin cytoskeleton organization

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Molecular Function
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Biological Process
External links
PDB RCSB:2wa7, PDBe:2wa7, PDBj:2wa7
PDBsum2wa7
PubMed19505475
UniProtO75369|FLNB_HUMAN Filamin-B (Gene Name=FLNB)

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