Structure of PDB 2wa5 Chain A

Receptor sequence
>2wa5A (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]
MAPVTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLR
LIALLEVLSQKRMYRKYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDS
KAIVDGNLKLILGLVWTLILHYSISMPVWEDEKQTPKQRLLGWIQNKIPY
LPITNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQKPVDNAREAMQQA
DDWLGVPQVITPEEIIHPDVDEHSVMTYLSQFPKAKL
3D structure
PDB2wa5 Disease-Associated Substitutions in the Filamin B Actin Binding Domain Confer Enhanced Actin Binding Affinity in the Absence of Major Structural Disturbance: Insights from the Crystal Structures of Filamin B Actin Binding Domains.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO3 A E218 I221 H222 E213 I216 H217
BS02 CO3 A H67 Q68 R69 H68 Q69 R70
Gene Ontology
Molecular Function
GO:0051015 actin filament binding
Biological Process
GO:0030036 actin cytoskeleton organization

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Molecular Function
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Biological Process
External links
PDB RCSB:2wa5, PDBe:2wa5, PDBj:2wa5
PDBsum2wa5
PubMed19505475
UniProtO75369|FLNB_HUMAN Filamin-B (Gene Name=FLNB)

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