Structure of PDB 2w8y Chain A

Receptor sequence
>2w8yA (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
LIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKW
SKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDL
ILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPL
EGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHD
LVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHK
3D structure
PDB2w8y The X-Ray Structure of Ru486 Bound to the Progesterone Receptor in a Destabilized Agonistic Conformation.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 486 A L715 L718 N719 L721 G722 E723 Q725 W755 M756 M759 F794 L797 Y890 C891 M909 L33 L36 N37 L39 G40 E41 Q43 W73 M74 M77 F112 L115 Y208 C209 M227 PDBbind-CN: -logKd/Ki=9.09,Ki=0.82nM
BindingDB: IC50=0.300000nM,Ki=1.1nM,EC50=>10000nM
External links
PDB RCSB:2w8y, PDBe:2w8y, PDBj:2w8y
PDBsum2w8y
PubMed19372222
UniProtP06401|PRGR_HUMAN Progesterone receptor (Gene Name=PGR)

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