Structure of PDB 2w68 Chain A

Receptor sequence
>2w68A (length=195) Species: 666 (Vibrio cholerae) [Search protein sequence]
AAMALFDYNATGDTEFDSPAKQGWMQDNTNNGSGVLTNADGMPAWLVQGI
GGRAQWTYSLSTNQHAQASSFGWRMTTEMKVLSGGMITNYYANGTQRVLP
IISLDSSGNLVVEFEGQTGRTVLATGTAATEYHKFELVFLPGSNPSASFY
FDGKLIRDNIQPTASKQNMIVWGNGSSNTDGVAAYRDIKFEIQGD
3D structure
PDB2w68 Enhancing the Receptor Affinity of the Sialic Acid-Binding Domain of Vibrio Cholerae Sialidase Through Multivalency
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SIA A R74 R118 Q188 G196 S198 R53 R97 Q167 G175 S177 PDBbind-CN: -logKd/Ki=4.74,Kd=18uM
Gene Ontology
Molecular Function
GO:0033691 sialic acid binding

View graph for
Molecular Function
External links
PDB RCSB:2w68, PDBe:2w68, PDBj:2w68
PDBsum2w68
PubMed19124471
UniProtP0C6E9|NANH_VIBCH Sialidase (Gene Name=nanH)

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