Structure of PDB 2w67 Chain A

Receptor sequence
>2w67A (length=642) Species: 226186 (Bacteroides thetaiotaomicron VPI-5482) [Search protein sequence]
LQPPPQQLIVQNKTIDLPAVYQLNGGEEANPHAVKVLKELLSGKQSKGML
ISIGEKGDKSVRKYSRQIPDHKEGYYLSVNEKEIVLAGNDERGTYYALQT
FAQLLKDGKLPEVEIKDYPSVRYRGVVEGFYGTPWSHQARLSQLKFYGKN
KMNTYIYGPKDDPYHSAPNWRLPYPDKEAAQLQELVAVANENEVDFVWAI
HPGQDIKWNKEDRDLLLAKFEKMYQLGVRSFAVFFDDISGEGTNPQKQAE
LLNYIDEKFAQVKPDINQLVMCPTEYNKSWSNPNGNYLTTLGDKLNPSIQ
IMWTGDRVISDITRDGISWINERIKRPAYIWWNFPVSDYVRDHLLLGPVY
GNDTTIAKEMSGFVTNPMEHAESSKIAIYSVASYAWNPAKYDTWQTWKDA
IRTILPSAAEELECFAMHNSDLGPNGHGYRREESMDIQPAAERFLKAFKE
GKNYDKADFETLQYTFERMKESADILLMNTENKPLIVEITPWVHQFKLTA
EMGEEVLKMVEGRNESYFLRKYNHVKALQQQMFYIDQTSNQNPYQPGVKT
ATRVIKPLIDRTFATVVKFFNQKFNAHLDATTDYMPHKMNLPLQVKANRV
LISPVEIELDAIYPGENIQINFGLQKAPVKFVRFQFVLTIEK
3D structure
PDB2w67 Molecular Basis for Inhibition of Gh84 Glycoside Hydrolases by Substituted Azepanes: Conformational Flexibility Enables Probing of Substrate Distortion.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.169: protein O-GlcNAcase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F34 A K166 D242 D243 Y282 V314 W337 N339 D344 K160 D236 D237 Y276 V308 W331 N333 D338 MOAD: Ki=11uM
PDBbind-CN: -logKd/Ki=4.96,Ki=11uM
BS02 CA A E32 E61 D64 E28 E55 D58
Gene Ontology
Molecular Function
GO:0015929 hexosaminidase activity
GO:0016231 beta-N-acetylglucosaminidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0042802 identical protein binding
GO:0102571 [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006517 protein deglycosylation
GO:1901135 carbohydrate derivative metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2w67, PDBe:2w67, PDBj:2w67
PDBsum2w67
PubMed19331390
UniProtQ89ZI2|OGA_BACTN O-GlcNAcase BT_4395 (Gene Name=BT_4395)

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