Structure of PDB 2w5b Chain A

Receptor sequence
>2w5bA (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
SRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQML
VSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGT
KERQYLDEEFVLRVMTQLTLALKECHRRSLHRDLKPANVFLDGKQNVKLG
DFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYE
LCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYH
RPSVEEILENPLILEHHHHHH
3D structure
PDB2w5b Insights Into the Conformational Variability and Regulation of Human Nek2 Kinase.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D141 K143 A145 N146 D159 H168 T179
Catalytic site (residue number reindexed from 1) D133 K135 A137 N138 D151 H160 T171
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS A I14 G15 G17 Y19 C22 K37 E87 Y88 C89 D93 F148 I12 G13 G15 Y17 C20 K35 E85 Y86 C87 D91 F140
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:2w5b, PDBe:2w5b, PDBj:2w5b
PDBsum2w5b
PubMed19124027
UniProtP51955|NEK2_HUMAN Serine/threonine-protein kinase Nek2 (Gene Name=NEK2)

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