Structure of PDB 2w4x Chain A

Receptor sequence
>2w4xA (length=579) Species: 226186 (Bacteroides thetaiotaomicron VPI-5482) [Search protein sequence]
SLQPPPQQLIVQNKTIDLPAVYQLNGGEEANPHAVKVLKELLSGMLISIG
EKGDKSVRKYSRQIPDHKEGYYLSVNEKEIVLAGNDERGTYYALQTFAQL
LKDGKLPEVEIKDYPSVRYRGVVEGFYGTPWSHQARLSQLKFYGKNKMNT
YIYGPKDDPYHSAPNWRLPYPDKEAAQLQELVAVANENEVDFVWAIHPGQ
DIKWNKEDRDLLLAKFEKMYQLGVRSFAVFFDDISGEGTNPQKQAELLNY
IDEKFAQVKPDINQLVMCPTEYNKSWSNPNGNYLTTLGDKLNPSIQIMWT
GDRVISDITRDGISWINERIKRPAYIWWNFPVSDYVRDHLLLGPVYGNDT
TIAKEMSGFVTNPMEHAESSKIAIYSVASYAWNPAKYDTWQTWKDAIRTI
LPSAAEELECFAMHNSDLGPNGHGYRREESMDIQPAAERFLKAFKEGKNY
DKADFETLQYTFERMKESADILLMNTENKPLIVEITPWVHQFKLTAEMGE
EVLKMVEGRNESYFLRKYNHVKALQQQMFYIDQTSNQNPYQPGVKTATRV
IKPLIDRTFATVVKFFNQKFNAHLDATTD
3D structure
PDB2w4x Structural Insight Into the Mechanism of Streptozotocin Inhibition of O-Glcnacase.
ChainA
Resolution2.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.169: protein O-GlcNAcase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STZ A G135 D242 Y282 V314 W337 D344 Y345 G125 D232 Y272 V304 W327 D334 Y335 MOAD: Kd=14uM
PDBbind-CN: -logKd/Ki=4.85,Kd=14uM
BS02 CA A E32 E61 D64 E29 E51 D54
Gene Ontology
Molecular Function
GO:0015929 hexosaminidase activity
GO:0016231 beta-N-acetylglucosaminidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0042802 identical protein binding
GO:0102571 [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006517 protein deglycosylation
GO:1901135 carbohydrate derivative metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2w4x, PDBe:2w4x, PDBj:2w4x
PDBsum2w4x
PubMed19217614
UniProtQ89ZI2|OGA_BACTN O-GlcNAcase BT_4395 (Gene Name=BT_4395)

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