Structure of PDB 2w4o Chain A

Receptor sequence
>2w4oA (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
IDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKIGVL
LRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAAD
AVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGTPGYCA
PEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEY
YFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVH
MDTAQKKLQEFNARRKLKAAVKAVVASS
3D structure
PDB2w4o Crystal Structure of Human Camk4 in Complex with 4-Amino(Sulfamoyl-Phenylamino)-Triazole- Carbothioic Acid (2,6-Difluoro-Phenyl)-Amide)
ChainA
Resolution2.17 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D164 K166 E168 N169 D185 T204
Catalytic site (residue number reindexed from 1) D121 K123 E125 N126 D142 T145
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DKI A L52 G53 V60 L120 V121 L171 A184 L19 G20 V27 L77 V78 L128 A141
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2w4o, PDBe:2w4o, PDBj:2w4o
PDBsum2w4o
PubMed
UniProtQ16566|KCC4_HUMAN Calcium/calmodulin-dependent protein kinase type IV (Gene Name=CAMK4)

[Back to BioLiP]