Structure of PDB 2w3n Chain A

Receptor sequence
>2w3nA (length=230) Species: 5207 (Cryptococcus neoformans) [Search protein sequence]
PFHAEPLKPSDEIDMDLGHSVAAQKFKEIREVLEGNRYWARKVTSEEPEF
MAEQVKGQAPNFLWIGCADSRVPEVTIMARKPGDVFVQRNVANQFKPEDD
SSQALLNYAIMNVGVTHVMVVGHTGCGGCIAAFDQPLPTEENPGGTPLVR
YLEPIIRLKHSLPEGSDVNDLIKENVKMAVKNVVNSPTIQGAWEQARKGE
FREVFVHGWLYDLSTGNIVDLNVTQGPHPF
3D structure
PDB2w3n Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans.
ChainA
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C68 D70 R72 H124 C127
Catalytic site (residue number reindexed from 1) C67 D69 R71 H123 C126
Enzyme Commision number 4.2.1.1: carbonic anhydrase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C68 H124 C127 C67 H123 C126
BS02 ACT A C68 D70 H124 C127 G128 C67 D69 H123 C126 G127
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0034599 cellular response to oxidative stress
GO:0071244 cellular response to carbon dioxide

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Molecular Function
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Biological Process
External links
PDB RCSB:2w3n, PDBe:2w3n, PDBj:2w3n
PDBsum2w3n
PubMed19071134
UniProtQ3I4V7

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