Structure of PDB 2w2i Chain A

Receptor sequence
>2w2iA (length=305) Species: 9606 (Homo sapiens) [Search protein sequence]
HTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMYDD
IEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPH
QNFADLEQRYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLE
QECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKTWYVV
PPEHGQHLERLARELFPDISAFLRHKVALISPTVLKENGIPFNCMTQEAG
EFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMAVTFSMDPFVRIV
QPESY
3D structure
PDB2w2i Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human Kdm4 Histone Demethylase Family.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G171 Y178 H189 E191 H277 A289
Catalytic site (residue number reindexed from 1) G159 Y166 H177 E179 H261 A273
Enzyme Commision number 1.14.11.66: [histone H3]-trimethyl-L-lysine(9) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PD2 A Y133 F186 H189 E191 K207 W209 K242 H277 Y121 F174 H177 E179 K195 W197 K226 H261 PDBbind-CN: -logKd/Ki=6.04,Ki=914nM
BindingDB: IC50=1400nM,Ki=914000nM
External links
PDB RCSB:2w2i, PDBe:2w2i, PDBj:2w2i
PDBsum2w2i
PubMed21914792
UniProtB2RXH2|KDM4E_HUMAN Lysine-specific demethylase 4E (Gene Name=KDM4E)

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