Structure of PDB 2w14 Chain A

Receptor sequence
>2w14A (length=202) Species: 8722 (Bothrops asper) [Search protein sequence]
ERFSPRYIELAVVADHGIFTKYNSNLNTIRTRVHEMLNTVNGFYRSVDVH
APLANLEVWSKQDLIKVQKDSSKTLKSFGEWRERDLLPRISHDHAQLLTA
VVFDGNTIGRAYTGGMCDPRHSVGVVRDHSKNNLWVAVTMAHELGHNLGI
HHDTGSCSCGAKSCIMASVLSKVLSYEFSDCSQNQYETYLTNHNPQCILN
KP
3D structure
PDB2w14 High-Resolution Crystal Structure of the Snake Venom Metalloproteinase Bap1 Complexed with a Peptidomimetic: Insight Into Inhibitor Binding.
ChainA
Resolution1.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H142 H146 H152 H142 H146 H152
BS02 WR2 A N106 T107 I108 G109 R110 H142 E143 H146 H152 S168 L170 N106 T107 I108 G109 R110 H142 E143 H146 H152 S168 L170 MOAD: ic50=22.2uM
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2w14, PDBe:2w14, PDBj:2w14
PDBsum2w14
PubMed19485419
UniProtP83512|VM1B1_BOTAS Snake venom metalloproteinase BaP1

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