Structure of PDB 2w0u Chain A

Receptor sequence
>2w0uA (length=334) Species: 9606 (Homo sapiens) [Search protein sequence]
LICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRML
RNVAETDLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLGTG
MMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKA
IFVTVDTPYLGNRLDDVRNRFKLPGLAAYVAKAIDPSISWEDIKWLRRLT
SLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIV
EAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIVWGLAFQGEKGV
QDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKN
3D structure
PDB2w0u Structure of Human Glycolate Oxidase in Complex with the Inhibitor 4-Carboxy-5-[(4-Chlorophenyl)Sulfanyl]-1,2,3-Thiadiazole.
ChainA
Resolution2.84 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S108 Y132 T158 D160 K236 H260
Catalytic site (residue number reindexed from 1) S104 Y128 T154 D156 K207 H231
Enzyme Commision number 1.1.3.15: (S)-2-hydroxy-acid oxidase.
1.2.3.5: glyoxylate oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C7C A Y26 M82 W110 Y132 R167 L205 Y208 V209 H260 R263 Y22 M78 W106 Y128 R163 L176 Y179 V180 H231 R234
BS02 FMN A Y27 A79 T80 A81 S108 Q130 T158 K236 H260 G261 R263 D291 G292 R295 G314 R315 Y23 A75 T76 A77 S104 Q126 T154 K207 H231 G232 R234 D262 G263 R266 G285 R286
Gene Ontology
Molecular Function
GO:0003973 (S)-2-hydroxy-acid oxidase activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0047969 glyoxylate oxidase activity
Biological Process
GO:0001561 fatty acid alpha-oxidation
GO:0006545 glycine biosynthetic process
GO:0006979 response to oxidative stress
GO:0008652 amino acid biosynthetic process
GO:0046296 glycolate catabolic process
Cellular Component
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2w0u, PDBe:2w0u, PDBj:2w0u
PDBsum2w0u
PubMed20054120
UniProtQ9UJM8|HAOX1_HUMAN 2-Hydroxyacid oxidase 1 (Gene Name=HAO1)

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