Structure of PDB 2vze Chain A

Receptor sequence
>2vzeA (length=533) Species: 9606 (Homo sapiens) [Search protein sequence]
HQEVPAKFNFASDVLDHWADMEKAGKRPPSPALWWVNGKGKELMWNFREL
SENSQQAANVLSGACGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIFMPG
TIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLRIKLLVSEK
SCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYS
SLGLKAKMDAGWTGLQASDIMWTISDTGWILNILCSLMEPWALGACTFVH
LLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCVT
VGESLLPETLENWRAQTGLDIRESYGQTETGLTCMVSKTMKIKPGYMGTA
ASCYDVQIIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPDKTAAN
IRGDFWLLGDRGIKDEDGYFQFMGRADDIINSSGYRIGPSEVENALMEHP
AVVETAVISSPDPVRGEVVKAFVVLASQFLSHDPEQLTKELQQHVKSVTA
PYKYPRKIEFVLNLPKTVTGKIQRAKLRDKEWK
3D structure
PDB2vze Structural Snapshots for the Conformation- Dependent Catalysis by Human Medium-Chain Acyl- Coenzyme a Synthetase Acsm2A.
ChainA
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) T221 T364 E365 N467 R472 K557
Catalytic site (residue number reindexed from 1) T185 T328 E329 N431 R436 K521
Enzyme Commision number 6.2.1.2: medium-chain acyl-CoA ligase.
6.2.1.25: benzoate--CoA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A W265 G338 E339 S340 E359 Y361 G362 Q363 T364 D446 F458 R461 R472 W229 G302 E303 S304 E323 Y325 G326 Q327 T328 D410 F422 R425 R436
Gene Ontology
Molecular Function
GO:0004321 fatty-acyl-CoA synthase activity
GO:0005524 ATP binding
GO:0015645 fatty acid ligase activity
GO:0016874 ligase activity
GO:0018858 benzoate-CoA ligase activity
GO:0031956 medium-chain fatty acid-CoA ligase activity
GO:0046872 metal ion binding
GO:0102391 decanoate-CoA ligase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006637 acyl-CoA metabolic process
GO:0036112 medium-chain fatty-acyl-CoA metabolic process
GO:0042593 glucose homeostasis
GO:0070328 triglyceride homeostasis
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2vze, PDBe:2vze, PDBj:2vze
PDBsum2vze
PubMed19345228
UniProtQ08AH3|ACS2A_HUMAN Acyl-coenzyme A synthetase ACSM2A, mitochondrial (Gene Name=ACSM2A)

[Back to BioLiP]