Structure of PDB 2vwv Chain A

Receptor sequence
>2vwvA (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
FAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLTERQRR
EFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLND
GQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDF
KIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVI
NAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRN
PASLK
3D structure
PDB2vwv Inhibitors of the Tyrosine Kinase Ephb4. Part 1: Structure-Based Design and Optimization of a Series of 2,4-Bis-Anilinopyrimidines
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D740 A742 R744 N745 D758 K781 P783
Catalytic site (residue number reindexed from 1) D131 A133 R135 N136 D149 K151 P153
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7X3 A I621 V629 A645 T693 M696 G699 L747 I16 V24 A40 T84 M87 G90 L138 MOAD: ic50=16uM
PDBbind-CN: -logKd/Ki=4.80,IC50=16uM
BindingDB: IC50=16000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2vwv, PDBe:2vwv, PDBj:2vwv
PDBsum2vwv
PubMed18434142
UniProtP54760|EPHB4_HUMAN Ephrin type-B receptor 4 (Gene Name=EPHB4)

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