Structure of PDB 2vwc Chain A

Receptor sequence
>2vwcA (length=213) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
ASETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYKSLS
DPKQLETEPDLFIRITPKPEQKVLEIRDSGIGMTKAELINNLGTIAKSGT
KAFMEALSAGADVSMIGQFGVGFYSLFLVADRVQVISKSNDDEQYIWESN
AGGSFTVTLDEVNERIGRGTILRLFLKDDQLEYLEEKRIKEVIKRHSEFV
AYPIQLVVTKEVE
3D structure
PDB2vwc Molecular Characterisation of Macbecin as an Hsp90 Inhibitor
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BC2 A N37 D40 A41 K44 M84 N92 L93 K98 G121 V122 F124 E214 N36 D39 A40 K43 M83 N91 L92 K97 G120 V121 F123 E213 MOAD: Kd=0.24uM
PDBbind-CN: -logKd/Ki=6.62,Kd=0.24uM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding

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Molecular Function
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Biological Process
External links
PDB RCSB:2vwc, PDBe:2vwc, PDBj:2vwc
PDBsum2vwc
PubMed18357975
UniProtP02829|HSP82_YEAST ATP-dependent molecular chaperone HSP82 (Gene Name=HSP82)

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