Structure of PDB 2vvs Chain A

Receptor sequence
>2vvsA (length=580) Species: 226186 (Bacteroides thetaiotaomicron VPI-5482) [Search protein sequence]
LQPPPQQLIVQNKTIDLPAVYQLNGGEEANPHAVKVLKELLGMLISIGEK
GDKSVRKYSRQIPDHKEGYYLSVNEKEIVLAGNDERGTYYALQTFAQLLK
DGKLPEVEIKDYPSVRYRGVVEGFYGTPWSHQARLSQLKFYGKNKMNTYI
YGPKDDPYHSAPNWRLPYPDKEAAQLQELVAVANENEVDFVWAIHPGQDI
KWNKEDRDLLLAKFEKMYQLGVRSFAVFFDDISGEGTNPQKQAELLNYID
EKFAQVKPDINQLVMCPTEYNKSWSNPNGNYLTTLGDKLNPSIQIMWTGD
RVISDITRDGISWINERIKRPAYIWWNFPVSDYVRDHLLLGPVYGNDTTI
AKEMSGFVTNPMEHAESSKIAIYSVASYAWNPAKYDTWQTWKDAIRTILP
SAAEELECFAMHNSDLGPNGHGYRREESMDIQPAAERFLKAFKEGKNYDK
ADFETLQYTFERMKESADILLMNTENKPLIVEITPWVHQFKLTAEMGEEV
LKMVEGRNESYFLRKYNHVKALQQQMFYIDQTSNQNPYQPGVKTATRVIK
PLIDRTFATVVKFFNQKFNAHLDATTDYMP
3D structure
PDB2vvs Elevation of Global O-Glcnac Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-Glcnacase Does not Induce Insulin Resistance
ChainA
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.169: protein O-GlcNAcase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OAN A G135 K166 D242 D243 Y282 W286 V314 W337 N339 D344 H433 G123 K154 D230 D231 Y270 W274 V302 W325 N327 D332 H421 MOAD: Ki=46nM
PDBbind-CN: -logKd/Ki=7.34,Ki=46nM
External links
PDB RCSB:2vvs, PDBe:2vvs, PDBj:2vvs
PDBsum2vvs
PubMed18842583
UniProtQ89ZI2|OGA_BACTN O-GlcNAcase BT_4395 (Gene Name=BT_4395)

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