Structure of PDB 2vvm Chain A

Receptor sequence

>2vvmA (length=481) Species: 5061 (Aspergillus niger)

MTSRDGYQWTPETGLTQGVPSLGVISPPTNIGPWDVIVIGGGYCGLTATR
DLTVAGFKTLLLEARDRIGGRSWSSNIDGYPYEMGGTWVHWHQSHVWREI
TRYKMHNALSPSFNFSRGVNHFQLRTNPTTSTYMTHEAEDELLRSALHKF
TNVDGTNGRTVLPFPHDMFYVPEFRKYDEMSYSERIDQIRDELSLNERSS
LEAFILLCSGGTLENSSFGEFLHWWAMSGYTYQGCMDCLMSYKFKDGQSA
FARRFWEEAAGTGRLGYVFGCPVRSVVNERDAARVTARDGREFVAKRVVC
TIPLNVLSTIQFSPALSTERISAMQAGHVSMCTKVHAEVDNKDMRSWTGI
AYPFNKLCYAIGDGTTPAGNTHLVCFGNSANHIQPDEDVRETLKAVGQLA
PGTFGVKRLVFHNWVKDEFAKGAWFFSRPGMVSECLQGLREKHGGVVFAN
SDWALGWRSFIDGAIEEGTRAARVVLEELGT

3D structure

• PDB: 2vvm The Structure of Monoamine Oxidase from Aspergillus Niger Provides a Molecular Context for Improvements in Activity Obtained by Directed Evolution.
• Chain: A
• Resolution: 1.85 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H96
• Catalytic site (residue number reindexed from 1): H90
• Enzyme Commision number: 1.4.3.4: monoamine oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G46 G48 C50 E69 A70 R71 G76 R77 G91 G92 T93 W94 P278 V279 I308 P309 W420 F425 A429 W430 N456 S457 S465 F466 I467 A470	G40 G42 C44 E63 A64 R65 G70 R71 G85 G86 T87 W88 P272 V273 I302 P303 W414 F419 A423 W424 N450 S451 S459 F460 I461 A464
BS02	PRO	A	W94 L213 F382 W430	W88 L207 F376 W424

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0097621 monoamine oxidase activity

Cellular Component

• GO:0005777 peroxisome

External links

• PDB: RCSB:2vvm, PDBe:2vvm, PDBj:2vvm
• PDBsum: 2vvm
• PubMed: 18951902
• UniProt: P46882|AOFN_ASPNG Monoamine oxidase N (Gene Name=maoN)