Structure of PDB 2vvl Chain A

Receptor sequence

>2vvlA (length=478) Species: 5061 (Aspergillus niger)

MTSRDGYQWTPETGLTQGVPSLGVISPPTNIWDVIVIGGGYCGLTATRDL
TVAGFKTLLLEARDRIGGRSWSSNIDGYPYEMGGTWVHWHQSHVWREITR
YKMHNALSPSFNFSRGVNHFQLRTNPTTSTYMTHEAEDELLRSALHKFTN
VDGTNGRTVLPFPHDMFYVPEFRKYDEMSYSERIDQIRDELSLNERSSLE
AFILLCSGGTLENSSFGEFLHWWAMSGYTYQGCMDCLMSYKFKDGQSAFA
RRFWEEAAGTGRLGYVFGCPVRSVVNERDAARVTARDGREFVAKRVVCTI
PLNVLSTIQFSPALSTERISAMQAGHVSMCTKVHAEVDNKDMRSWTGIAY
PFNKLCYAIGDGTTPAGNTHLVCFGTDANHIQPDEDVRETLKAVGQLAPG
TFGVKRLVFHNWVKDEFAKGAWFFSRPGMVSECLQGLREKHGGVVFANSD
WALGWRSFIDGAIEEGTRAARVVLEELG

3D structure

• PDB: 2vvl The Structure of Monoamine Oxidase from Aspergillus Niger Provides a Molecular Context for Improvements in Activity Obtained by Directed Evolution.
• Chain: A
• Resolution: 2.45 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H96
• Catalytic site (residue number reindexed from 1): H88
• Enzyme Commision number: 1.4.3.4: monoamine oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G46 G48 C50 E69 A70 R71 G76 R77 G91 G92 T93 W94 P278 V279 I308 P309 W420 F425 A429 W430 N456 S457 S465 F466 I467 A470	G38 G40 C42 E61 A62 R63 G68 R69 G83 G84 T85 W86 P270 V271 I300 P301 W412 F417 A421 W422 N448 S449 S457 F458 I459 A462

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0097621 monoamine oxidase activity

Cellular Component

• GO:0005777 peroxisome

External links

• PDB: RCSB:2vvl, PDBe:2vvl, PDBj:2vvl
• PDBsum: 2vvl
• PubMed: 18951902
• UniProt: P46882|AOFN_ASPNG Monoamine oxidase N (Gene Name=maoN)