Structure of PDB 2vux Chain A

Receptor sequence
>2vuxA (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
NEEPLLRKVIFPIQYPDIWKMYKQAQASFWTAEEVDLSKDLPHWNKLKAD
EKYFISHILAFFAASNLVERFSQEVQVPEARCFYGFQILIENVHSEMYSL
LIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAF
AAVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQ
YLVNKPSEERVREIIVDAVKIEQEFLTEALPVGLIGMNCILMKQYIEFVA
DRLLVELGFSKVFQAENPFDFM
3D structure
PDB2vux Human Ribonucleotide Reductase, Subunit M2 B
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y138 D227
Catalytic site (residue number reindexed from 1) Y98 D187
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A E131 E194 E228 H231 E91 E154 E188 H191
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
Biological Process
GO:0009263 deoxyribonucleotide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2vux, PDBe:2vux, PDBj:2vux
PDBsum2vux
PubMed
UniProtQ7LG56|RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B (Gene Name=RRM2B)

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