Structure of PDB 2vu9 Chain A

Receptor sequence
>2vu9A (length=425) Species: 36826 (Clostridium botulinum A) [Search protein sequence]
HMDTSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESS
KIEVILKNAIVYNSMYENFSTSFWIRIPKYFNSISLNNEYTIINCMENNS
GWKVSLNYGEIIWTLQDTQEIKQRVVFKYSQMINISDYINRWIFVTITNN
RLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYF
NLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKY
VDVNNVGIRGYMYLKGPRGSVMTTNIYLNSSLYRGTKFIIKKYASGNKDN
IVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSALEIPDVGNLSQVVV
MKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWYNRQIE
RSSRTLGCSWEFIPVDDGWGERPLQ
3D structure
PDB2vu9 Crystal Structure of Botulinum Neurotoxin Type a in Complex with the Cell Surface Co-Receptor Gt1B- Insight Into the Toxin-Neuron Interaction.
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q913 N979
Catalytic site (residue number reindexed from 1) Q41 N107
Enzyme Commision number 3.4.24.69: bontoxilysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GAL A E1203 F1252 H1253 S1264 W1266 E331 F380 H381 S392 W394
BS02 SIA A Y1117 F1252 S1275 Y245 F380 S403
BS03 MG A D1089 N1093 D217 N221
Gene Ontology
Cellular Component
GO:0005576 extracellular region

View graph for
Cellular Component
External links
PDB RCSB:2vu9, PDBe:2vu9, PDBj:2vu9
PDBsum2vu9
PubMed18704164
UniProtP0DPI1|BXA1_CLOBH Botulinum neurotoxin type A (Gene Name=botA)

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