Structure of PDB 2vsx Chain A

Receptor sequence
>2vsxA (length=366) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
QIQTNYDKVVYKFDDMELDENLLRGVFGYGFEEPSAIQQRAIMPIIEGHD
VLAQAQSGTGKTGTFSIAALQRIDTSVKAPQALMLAPTRELALQIQKVVM
ALAFHMDIKVHACIGLRDAQIVVGTPGRVFDNIQRRRFRTDKIKMFILDE
ADEMLSSGFKEQIYQIFTLLPPTTQVVLLSATMPNDVLEVTTKFMRNPVR
ILVKKDELTLEGIKQFYVNVEEEEYKYECLTDLYDSISVTQAVIFCNTRR
KVEELTTKLRNDKFTVSAIYSDLPQQERDTIMKEFRSGSSRILISTDLLA
RGIDVQQVSLVINYDLPANKENYIHRIGRKGVAINFVTNEDVGAMRELEK
FYSTQIEELPSDIATL
3D structure
PDB2vsx Crystal Structure of the Yeast Eif4A-Eif4G Complex: An RNA-Helicase Controlled by Protein-Protein Interactions.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A F42 Q49 G69 G71 K72 T73 F31 Q38 G58 G60 K61 T62
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003743 translation initiation factor activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008186 ATP-dependent activity, acting on RNA
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:1901195 positive regulation of formation of translation preinitiation complex
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0005886 plasma membrane
GO:0010494 cytoplasmic stress granule
GO:0016281 eukaryotic translation initiation factor 4F complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2vsx, PDBe:2vsx, PDBj:2vsx
PDBsum2vsx
PubMed18606994
UniProtP10081|IF4A_YEAST ATP-dependent RNA helicase eIF4A (Gene Name=TIF1)

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