Structure of PDB 2vr1 Chain A

Receptor sequence
>2vr1A (length=444) Species: 562 (Escherichia coli) [Search protein sequence]
MLDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLKHVLLADETVC
IGPAPSVKSYLNIPAIISAAEITGAVAIHPGYGFLSENANFAEQVERSGF
IFIGPKAETIRLMGDKVSAIAAMKKAGVPCVPGSDGPLGDDMDKNRAIAK
RIGYPVIIKASGGGRGMRVVRGDAELAQSISMTRAEAKAAFSNDMVYMEK
YLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVVEEAPAPGITPEL
RRYIGERCAKACVDIGYRGAGTFEFLFENGEFYFIEMNTRIQVEHPVTEM
ITGVDLIKEQLRIAAGQPLSIKQEEVHVRGHAVECRINAEDPNTFLPSPG
KITRFHAPGGFGVRWESHIYAGYTVPPYYDSMIGKLICYGENRDVAIARM
KNALQELIIDGIKTNVDLQIRIMNDENFQHGGTNIHYLEKKLGL
3D structure
PDB2vr1 Structural Evidence for Substrate-Induced Synergism and Half-Sites Reactivity in Biotin Carboxylase.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K116 K159 D196 H209 R235 T274 E276 E288 N290 R292 E296 R338
Catalytic site (residue number reindexed from 1) K116 K159 D194 H207 R233 T272 E274 E286 N288 R290 E294 R336
Enzyme Commision number 6.3.4.14: biotin carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATF A K159 R167 M169 Y203 L204 E276 L278 E288 N290 I437 K159 R165 M167 Y201 L202 E274 L276 E286 N288 I435
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003989 acetyl-CoA carboxylase activity
GO:0004075 biotin carboxylase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:2001295 malonyl-CoA biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009317 acetyl-CoA carboxylase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2vr1, PDBe:2vr1, PDBj:2vr1
PDBsum2vr1
PubMed18725455
UniProtP24182|ACCC_ECOLI Biotin carboxylase (Gene Name=accC)

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