Structure of PDB 2vqr Chain A

Receptor sequence

>2vqrA (length=512) Species: 216596 (Rhizobium johnstonii 3841)

KKNVLLIVVDQWRADFVPHVLRADGKIDFLKTPNLDRLCREGVTFRNHVT
TCVPAGPARASLLTGLYLMNHRAVQNTVPLDQRHLNLGKALRGVGYDPAL
IGYTTTVPDPRTTSPNDPRFRVLGDLMDGFHPVGAFEPNMEGYFGWVAQN
GFDLPEHRPDIWLPEGEDAVAGATDRPSRIPKEFSDSTFFTERALTYLKG
RDGKPFFLHLGYYRPHPPFVASAPYHAMYRPEDMPAPIRAANPDIEAAQH
PLMKFYVDSIRRGSFFQGAEGSGATLDEAELRQMRATYCGLITEVDDCLG
RVFSYLDETGQWDDTLIIFTSDHGEQLGDHHLLGKIGYNDPSFRIPLVIK
DAGENARAGAIESGFTESIDVMPTILDWLGGKIPHACDGLSLLPFLSEGR
PQDWRTELHYEYDFRDVYYSEPQSFLGLGMNDCSLCVIQDERYKYVHFAA
LPPLFFDLRHDPNEFTNLADDPAYAALVRDYAQKALSWRLKHADRTLTHY
RSGPEGLSERSH

3D structure

• PDB: 2vqr A New Member of the Alkaline Phosphatase Superfamily with a Formylglycine Nucleophile: Structural and Kinetic Characterisation of a Phosphonate Monoester Hydrolase/Phosphodiesterase from Rhizobium Leguminosarum.
• Chain: A
• Resolution: 1.42 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D12 Q13 A57 R61 Y105 T107 H218 D324 H325 K337
• Catalytic site (residue number reindexed from 1): D10 Q11 A55 R59 Y103 T105 H216 D322 H323 K335
• Enzyme Commision number: 3.1.3.-
  3.1.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	A	D12 X57 D324 H325	D10 X55 D322 H323
BS02	CA	A	D12 X57 D324 H325	D10 X55 D322 H323

Gene Ontology

Molecular Function

• GO:0008484 sulfuric ester hydrolase activity
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2vqr, PDBe:2vqr, PDBj:2vqr
• PDBsum: 2vqr
• PubMed: 18793651
• UniProt: Q1M964|RLPMH_RHIJ3 Multifunctional alkaline phosphatase superfamily protein pRL90232 (Gene Name=pRL90232)