Structure of PDB 2vqq Chain A

Receptor sequence
>2vqqA (length=361) Species: 9606 (Homo sapiens) [Search protein sequence]
RFTTGLVYDTLMLKHQHAGRIQSIWSRLQETGLRGKCEAIRGRKATLEEL
QTVHSEAHTLLYGTNPLVDSDTIWNEVHSAGAARLAVGCVVELVFKVATG
ELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVD
WDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGF
NVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEG
HPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEAC
VSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTA
GRSLIEAQTCE
3D structure
PDB2vqq Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TFG A P156 H159 G167 F168 D196 H198 F227 G330 P112 H115 G123 F124 D152 H154 F183 G286 MOAD: ic50=367nM
BS02 ZN A D196 H198 D290 D152 H154 D246
BS03 TFG A L78 Y79 A124 L61 Y62 A80 MOAD: ic50=367nM
External links
PDB RCSB:2vqq, PDBe:2vqq, PDBj:2vqq
PDBsum2vqq
PubMed18614528
UniProtP56524|HDAC4_HUMAN Histone deacetylase 4 (Gene Name=HDAC4)

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