Structure of PDB 2vqo Chain A

Receptor sequence
>2vqoA (length=360) Species: 9606 (Homo sapiens) [Search protein sequence]
RFTTGLVYDTLMLKHQAGRIQSIWSRLQETGLRGKCEAIRGRKATLEELQ
TVHSEAHTLLYGTNPLVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGE
LKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDW
DVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFN
VNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGH
PTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGYDLTAICDASEACV
SALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAG
RSLIEAQTCE
3D structure
PDB2vqo Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TFG A P156 H159 G167 F168 H198 F227 L299 G330 P111 H114 G122 F123 H153 F182 L254 G285 MOAD: ic50=317nM
BS02 ZN A D196 H198 D290 D151 H153 D245
BS03 TFG A L78 Y79 V121 A124 L60 Y61 V76 A79 MOAD: ic50=317nM
External links
PDB RCSB:2vqo, PDBe:2vqo, PDBj:2vqo
PDBsum2vqo
PubMed18614528
UniProtP56524|HDAC4_HUMAN Histone deacetylase 4 (Gene Name=HDAC4)

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