Structure of PDB 2vqm Chain A

Receptor sequence
>2vqmA (length=391) Species: 9606 (Homo sapiens) [Search protein sequence]
PRFTTGLVYDTLMLKHQCTCGHAGRIQSIWSRLQETGLRGKCECIRGRKA
TLEELQTVHSEAHTLLYGTNPLNRQKKLLGSLASVFVRLPCGGVGVDSDT
IWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPM
GFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYM
SLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAA
FRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL
MGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPN
ANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENE
3D structure
PDB2vqm Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HA3 A P156 G167 F168 H198 F227 P140 G151 F152 H182 F211 MOAD: ic50=978nM
PDBbind-CN: -logKd/Ki=6.01,IC50=978nM
BS02 ZN A D196 H198 D290 D180 H182 D274
BS03 ZN A H21 C23 H34 C107 H16 C18 H22 C91
External links
PDB RCSB:2vqm, PDBe:2vqm, PDBj:2vqm
PDBsum2vqm
PubMed18614528
UniProtP56524|HDAC4_HUMAN Histone deacetylase 4 (Gene Name=HDAC4)

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