Structure of PDB 2vqj Chain A

Receptor sequence
>2vqjA (length=402) Species: 9606 (Homo sapiens) [Search protein sequence]
PRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCE
CIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRL
PCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRP
PGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQ
AFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLD
PPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLS
ARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDP
LPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCE
NE
3D structure
PDB2vqj Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TFG A P156 H159 G167 F168 D196 H198 F227 G330 P151 H154 G162 F163 D191 H193 F222 G325 PDBbind-CN: -logKd/Ki=6.44,IC50=367nM
BS02 ZN A D196 H198 D290 D191 H193 D285
BS03 ZN A H21 C23 H34 H16 C18 H29
External links
PDB RCSB:2vqj, PDBe:2vqj, PDBj:2vqj
PDBsum2vqj
PubMed18614528
UniProtP56524|HDAC4_HUMAN Histone deacetylase 4 (Gene Name=HDAC4)

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