Structure of PDB 2vqb Chain A

Receptor sequence

>2vqbA (length=443) Species: 230105 (Methylophaga aminisulfidivorans) [Search protein sequence]

TRIAILGAGPSGMAQLRAFQSAQEKGAEIPELVCFEKQADWGGQWNYTWR
TGLDENGEPVHSSMYRYLWSNGPKECLEFADYTFDEHFGKPIASYPPREV
LWDYIKGRVEKAGVRKYIRFNTAVRHVEFNEDSQTFTVTVQDHTTDTIYS
AAFDYVVCCTGHFSTPYVPEFEGFEKFGGRILHAHDFRDALEFKDKTVLL
VGSSYSAEDIGSQCYKYGAKKLISCYRTAPMGYKWPENWDERPNLVRVDT
ENAYFADGSSEKVDAIILCTGYIHHFPFLNDDLRLVTNNRLWPLNLYKGV
VWEDNPKFFYIGMQDQWYSFNMFDAQAWYARDVIMGRLPLPSKEEMKADS
MAWREKELTLVTAEEMYTYQGDYIQNLIDMTDYPSFDIPATNKTFLEWKH
HKKENIMTFRDHSYRSLMTGTMAPKHHTPWIDALDDSLEAYLS

3D structure

PDB

2vqb Revealing the Moonlighting Role of Nadp in the Structure of a Flavin-Containing Monooxygenase.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.13.148: trimethylamine monooxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G14 G16 P17 S18 E43 K44 Q45 G50 Q51 W52 H68 S70 M71 S77 N78 A130 V131 C166 T167 F170 Q323 S326 F330	G7 G9 P10 S11 E36 K37 Q38 G43 Q44 W45 H61 S63 M64 S70 N71 A123 V124 C159 T160 F163 Q316 S319 F323
BS02	NAP	A	N78 F170 P176 S210 S211 Y212 S213 D216 R234 N251 C276 T277	N71 F163 P169 S203 S204 Y205 S206 D209 R227 N244 C269 T270

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0004497	monooxygenase activity
GO:0004499	N,N-dimethylaniline monooxygenase activity
GO:0042802	identical protein binding
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

View graph for
Molecular Function

External links

PDB	RCSB:2vqb, PDBe:2vqb, PDBj:2vqb
PDBsum	2vqb
PubMed	18443301
UniProt	Q83XK4

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