Structure of PDB 2vos Chain A

Receptor sequence
>2vosA (length=448) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
DEIASLLQVEHLLDQRWRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNG
KTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATY
REIEPLVALIDQQSQASPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGG
RWDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPSPDTV
AVIGRQVPKVMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQG
LGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAQLDGDAVRAGFAAVTS
PGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLVGVLSVLGDK
DVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAEN
LRDAIDVATSLVDDAAADPDVAGRTGIVITGSVVTAGAARTLFGRDPQ
3D structure
PDB2vos Structures of Mycobacterium Tuberculosisfolylpolyglutamate Synthase Complexed with Adp and Amppcp.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.17: tetrahydrofolate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A T74 N75 G76 K77 T78 S79 H299 N303 R340 D353 A355 G360 A363 T48 N49 G50 K51 T52 S53 H266 N270 R303 D316 A318 G323 A326
BS02 MG A D202 H356 D171 H319
BS03 CO A T78 S100 E176 T52 S74 E145
BS04 CO A H203 D205 H172 D174
BS05 CO A D455 D457 D418 D420
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004326 tetrahydrofolylpolyglutamate synthase activity
GO:0005524 ATP binding
GO:0008841 dihydrofolate synthase activity
GO:0016874 ligase activity
GO:0016881 acid-amino acid ligase activity
GO:0043531 ADP binding
GO:0046872 metal ion binding
GO:0050897 cobalt ion binding
Biological Process
GO:0006761 dihydrofolate biosynthetic process
GO:0009058 biosynthetic process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2vos, PDBe:2vos, PDBj:2vos
PDBsum2vos
PubMed18566510
UniProtO53174

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