Structure of PDB 2vnt Chain A

Receptor sequence
>2vntA (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
KFQCGQKTLIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLMSPCWV
ISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADT
LAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFG
KENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKT
DSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWI
RSHTKEE
3D structure
PDB2vnt Selective Urokinase-Type Plasminogen Activator (Upa) Inhibitors 4. 1-(7-Sulphonamidoisoquinolinyl) Guanidines
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H55 D106 Q204 G205 D206 S207 G208
Catalytic site (residue number reindexed from 1) H55 D106 Q204 G205 D206 S207 G208
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QGG A D201 S202 Q204 S207 V225 W227 G228 R229 G230 C231 D201 S202 Q204 S207 V225 W227 G228 R229 G230 C231 MOAD: Ki=9.9nM
PDBbind-CN: -logKd/Ki=8.00,Ki=9.9nM
BindingDB: Ki=9.9nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2vnt, PDBe:2vnt, PDBj:2vnt
PDBsum2vnt
PubMed17447747
UniProtP00749|UROK_HUMAN Urokinase-type plasminogen activator (Gene Name=PLAU)

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