Structure of PDB 2vl8 Chain A

Receptor sequence
>2vl8A (length=539) Species: 1505 (Paraclostridium sordellii) [Search protein sequence]
MNLVNKAQLQKMAYVKFRIQEDEYVAILNALEEYHNMSESSVVEKYLKLK
DINNLTDNYLNTYKKSGRNKALKKFKEYLTMEVLELKNNSLTPVEKNLHF
IWIGGQINDTAINYINQWKDVNSDYTVKVFYDSNAFLINTLKKTIVESAT
NNTLESFRENLNDPEFDYNKFYRKRMEIIYDKQKHFIDYYKSQIEENPEF
IIDNIIKTYLSNEYSKDLEALNKYIEESLNKITANNGNDIRNLEKFADED
LVRLYNQELVERWNLAAASDILRISMLKEDGGVYLDVDMLPGIQPDLFKS
INKPDSITNTSWEMIKLEAIMKYKEYIPGYTSKNFDMLDEEVQRSFESAL
SSKSDKSEIFLPLDDIKVSPLEVKIAFANNSVINQALISLKDSYCSDLVI
NQIKNRYKILNDNLNPSINEGTDFNTTMKIFSDKLASISNEDNMMFMIKI
TNYLKVGFAPDVRSTINLSGPGVYTGAYQDLLMFKDNSTNIHLLEPELRN
FEFPKTKISQLTEQEITSLWSARAKSQFEEYKKGYFEGA
3D structure
PDB2vl8 Inhibition of the Glucosyltransferase Activity of Clostridial Rho/Ras-Glucosylating Toxins by Castanospermine.
ChainA
Resolution2.31 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.4.1.-
3.4.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDP A I101 W102 I103 L265 S269 D286 V287 I101 W102 I103 L265 S269 D286 V287 PDBbind-CN: -logKd/Ki=4.52,IC50=30uM
BS02 CTS A D270 R273 D286 N384 T465 D270 R273 D286 N384 T465 MOAD: ic50~30uM
BS03 CA A D288 E515 S518 D288 E515 S518
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:2vl8, PDBe:2vl8, PDBj:2vl8
PDBsum2vl8
PubMed18505687
UniProtQ46342|TCSL1_PARSO Cytotoxin-L (Gene Name=tcsL)

[Back to BioLiP]