Structure of PDB 2vkv Chain A

Receptor sequence
>2vkvA (length=200) Species: 562 (Escherichia coli) [Search protein sequence]
KSKVINSALELGNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDAL
AVEILARHHDYSLPAAGESWQSFLRNNAMSFRRALLRYRDGAKVHLGTRP
DEKQYDTVETQLRFMTENGFSLRDGLYAISAVSHFTLGAVLEQQEHTAAL
TDRPAAPDENLPPLLREALQIMDSDDGEQAFLHGLESLIRGFEVQLTALL
3D structure
PDB2vkv A Protein Functional Leap: How a Single Mutation Reverses the Function of the Transcription Regulator Tetr.
ChainA
Resolution1.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TDC A H64 N82 F86 H100 P105 V113 Q116 S138 H59 N77 F81 H95 P100 V108 Q111 S133 MOAD: Ka=45000000M^-1
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:2vkv, PDBe:2vkv, PDBj:2vkv
PDBsum2vkv
PubMed18587152
UniProtP0ACT4|TETR4_ECOLX Tetracycline repressor protein class D (Gene Name=tetR)

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