Structure of PDB 2vk7 Chain A

Receptor sequence
>2vk7A (length=448) Species: 1502 (Clostridium perfringens) [Search protein sequence]
VEGAVKTEPVDLFHPGFLNSSNYRIPALFKTKEGTLIASIDARRHGGADA
PNNDIDTAVRRSEDGGKTWDEGQIIMDYPDKSSVIDTTLIQDDETGRIFL
LVTHFPSKYGFWNAGLGSGFKNIDGKEYLCLYDSSGKEFTVRENVVYDKD
SNKTEYTTNALGDLFKNGTKIDNINSSTAPLKAKGTSYINLVYSDDDGKT
WSEPQNINFQVKKDWMKFLGIAPGRGIQIKNGEHKGRIVVPVYYTNEKGK
QSSAVIYSDDSGKNWTIGESPNDNRKLENGKIINSKTLSDDAPQLTECQV
VEMPNGQLKLFMRNLSGYLNIATSFDGGATWDETVEKDTNVLEPYCQLSV
INYSQKVDGKDAVIFSNPNARSRSNGTVRIGLINQVGTYENGEPKYEFDW
KYNKLVKPGYYAYSCLTELSNGNIGLLYEGTPSEEMSYIEMNLKYLES
3D structure
PDB2vk7 The Structure of Clostridium Perfringens Nani Sialidase and its Catalytic Intermediates.
ChainA
Resolution1.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A1290 D1291 E1539 Y1655
Catalytic site (residue number reindexed from 1) A48 D49 E297 Y413
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D1515 N1516 W1573 D273 N274 W331
BS02 FSI A R1266 I1267 D1291 I1327 D1328 F1353 Y1485 Q1493 R1555 R1615 Y1655 R24 I25 D49 I85 D86 F111 Y243 Q251 R313 R373 Y413
BS03 CA A D1296 D1298 D1319 Y1320 D54 D56 D77 Y78
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity

View graph for
Molecular Function
External links
PDB RCSB:2vk7, PDBe:2vk7, PDBj:2vk7
PDBsum2vk7
PubMed18218621
UniProtQ59310

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