Structure of PDB 2vgp Chain A

Receptor sequence
>2vgpA (length=266) Species: 8355 (Xenopus laevis) [Search protein sequence]
FTIDDFDIGRPLGKGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRR
EIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDE
QRSATFMEELADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVH
APSLRRRTMCGTLDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFD
SPSHTETHRRIVNVDLKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEH
PWVKANSRRVLPPVYQ
3D structure
PDB2vgp Discovery of Selective Aminothiazole Aurora Kinase Inhibitors
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D216 K218 E220 N221 D234 T252
Catalytic site (residue number reindexed from 1) D126 K128 E130 N131 D144 T162
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AD6 A L99 F172 A173 G176 L223 L12 F82 A83 G86 L133 MOAD: ic50=577nM
PDBbind-CN: -logKd/Ki=6.85,IC50=0.14uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2vgp, PDBe:2vgp, PDBj:2vgp
PDBsum2vgp
PubMed18307303
UniProtQ6DE08|AUKBA_XENLA Aurora kinase B-A (Gene Name=aurkb-a)

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