Structure of PDB 2vdw Chain A

Receptor sequence
>2vdwA (length=296) Species: 10245 (Vaccinia virus) [Search protein sequence]
DKFRLNPEVSYFTNKRTRGPLGILSNYVKTLLISMYCSKTFLDDSNKRKV
LAIDFGNGADLEKYFYGEIALLVATDPDADAIARGNERYNKLNSKYYKFD
YIQETIRSDTFVSSVREVFYFGKFNIIDWQFAIHYSFHPRHYATVMNNLS
ELTASGGKVLITTMDGDKLSKLTDKKTFIIHKNLPSSENYMSVEKIADDR
IVVYNPSTMSTPMTEYIIKKNDIVRVFNEYGFVLVDNVDFATIIERSKKF
INGASTMEDRPSTRNFFELNRGAIKCEGLDVEDLLSYYVVYVFSKR
3D structure
PDB2vdw Structural Insights Into the Mechanism and Evolution of the Vaccinia Virus Mrna CAP N7 Methyl- Transferase.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.7.7.50: mRNA guanylyltransferase.
3.6.1.74: mRNA 5'-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A R548 L549 N550 Y555 F556 K573 D598 F599 G600 D620 P621 R655 Q678 F679 Y683 R4 L5 N6 Y11 F12 K29 D54 F55 G56 D76 P77 R107 Q130 F131 Y135
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:2vdw, PDBe:2vdw, PDBj:2vdw
PDBsum2vdw
PubMed17989694
UniProtP04298|MCEL_VACCW mRNA-capping enzyme catalytic subunit (Gene Name=OPG113)

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