Structure of PDB 2vdr Chain A

Receptor sequence

>2vdrA (length=452) Species: 9606 (Homo sapiens)

LNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEET
GGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSW
SDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNT
LSRIYVENDFSWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPV
ADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNT
TEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNG
DGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGT
QLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLR
SRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRA
QP

3D structure

• PDB: 2vdr Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
• Chain: A
• Resolution: 2.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	Y189 Y190 L192 D224 S225 F231	Y189 Y190 L192 D224 S225 F231
BS02	CA	A	E243 D245 D247 T250 E252	E243 D245 D247 T250 E252
BS03	CA	A	D297 N299 D301 R303 D305	D297 N299 D301 R303 D305
BS04	CA	A	D365 D367 D369 Y371 D373	D365 D367 D369 Y371 D373
BS05	CA	A	D426 D428 N430 Y432 D434	D426 D428 N430 Y432 D434

Gene Ontology

Biological Process

• GO:0007155 cell adhesion

Cellular Component

• GO:0008305 integrin complex

External links

• PDB: RCSB:2vdr, PDBe:2vdr, PDBj:2vdr
• PDBsum: 2vdr
• PubMed: 18710925
• UniProt: P08514|ITA2B_HUMAN Integrin alpha-IIb (Gene Name=ITGA2B)