Structure of PDB 2vbq Chain A

Receptor sequence
>2vbqA (length=147) [Search protein sequence]
SHMDIRQMNKTHLEHWRGLRKQLWPGHPDDAHLADGEEILQADHLASFIA
MADGVAIGFADASIRHDYVNGCDSSPVVFLEGIFVLPSFRQRGVAKQLIA
AVQRWGTNKGCREMASDTSPENTISQKVHQALGFEETERVIFYRKRC
3D structure
PDB2vbq Kinetic and Structural Analysis of Bisubstrate Inhibition of the Salmonella Enterica Aminoglycoside 6'-N-Acetyltransferase.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.82: aminoglycoside 6'-N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BSJ A L21 W22 E79 G80 I81 F82 V83 R88 Q89 G91 V92 A93 K94 D115 N120 I122 S123 V126 A129 L130 L23 W24 E81 G82 I83 F84 V85 R90 Q91 G93 V94 A95 K96 D117 N122 I124 S125 V128 A131 L132 MOAD: Ki<41uM
BS02 BSJ A Y66 E136 Y68 E138 MOAD: Ki<41uM
Gene Ontology
Molecular Function
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0042803 protein homodimerization activity
GO:0047663 aminoglycoside 6'-N-acetyltransferase activity
Biological Process
GO:0006084 acetyl-CoA metabolic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:2vbq, PDBe:2vbq, PDBj:2vbq
PDBsum2vbq
PubMed18095712
UniProtQ9R381|AAC6_SALEN Aminoglycoside N(6')-acetyltransferase type 1

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