Structure of PDB 2v8f Chain A

Receptor sequence
>2v8fA (length=139) Species: 10090 (Mus musculus) [Search protein sequence]
AGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPVEIDMI
VGKDREGFFTNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNV
AVGRAGRVLVFVMGKEGVHGGGLNKKAYSMAKYLRDSGF
3D structure
PDB2v8f High-Resolution Structural Analysis of Mammalian Profilin 2A Complex Formation with Two Physiological Ligands: The Formin Homology 1 Domain of Mdia1 and the Proline-Rich Domain of Vasp.
ChainA
Resolution1.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A W3 S5 Y6 W31 R107 Y133 S137 F139 W3 S5 Y6 W31 R107 Y133 S137 F139
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0003785 actin monomer binding
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0010633 negative regulation of epithelial cell migration
GO:0030036 actin cytoskeleton organization
GO:0030837 negative regulation of actin filament polymerization
GO:0030838 positive regulation of actin filament polymerization
GO:0032233 positive regulation of actin filament bundle assembly
GO:0032781 positive regulation of ATP-dependent activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0044087 regulation of cellular component biogenesis
GO:0050804 modulation of chemical synaptic transmission
GO:0050821 protein stabilization
GO:0051496 positive regulation of stress fiber assembly
GO:0098885 modification of postsynaptic actin cytoskeleton
GO:0099140 presynaptic actin cytoskeleton organization
GO:0099171 presynaptic modulation of chemical synaptic transmission
GO:0110053 regulation of actin filament organization
GO:1900028 negative regulation of ruffle assembly
GO:2000300 regulation of synaptic vesicle exocytosis
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098793 presynapse
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2v8f, PDBe:2v8f, PDBj:2v8f
PDBsum2v8f
PubMed18001770
UniProtQ9JJV2|PROF2_MOUSE Profilin-2 (Gene Name=Pfn2)

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