Structure of PDB 2v4b Chain A

Receptor sequence
>2v4bA (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
SHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLV
VVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAIL
FTRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGH
VFNMPHDDAKQCASLNSHMMASMLDHSQPWSPCSAYMITSFLDNGHGECL
MDKPQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPTCSTLWCTGVLVC
QTKHFPWADGTSCGEGKWCINGKCVNKLVP
3D structure
PDB2v4b Crystal Structures of Human Adamts-1 Reveal a Conserved Catalytic Domain and a Disintegrin-Like Domain with a Fold Homologous to Cysteine-Rich Domains.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H401 H405 H411 H146 H150 H156
BS02 MG A H439 D530 N542 H176 D259 N271
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2v4b, PDBe:2v4b, PDBj:2v4b
PDBsum2v4b
PubMed17897672
UniProtQ9UHI8|ATS1_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 1 (Gene Name=ADAMTS1)

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