Structure of PDB 2v1u Chain A

Receptor sequence

>2v1uA (length=382) Species: 56636 (Aeropyrum pernix)

LESKIFRKRWVLLPDYVPDVLPHREAELRRLAEVLAPALRGEKPSNALLY
GLTGTGKTAVARLVLRRLEARASSLGVLVKPIYVNARHRETPYRVASAIA
EAVGVRVPFTGLSVGEVYERLVKRLSRLRGIYIIVLDEIDFLPKRPGGQD
LLYRITRINQELVSLVGITNSLGFVENLEPRVKSSLGEVELVFPPYTAPQ
LRDILETRAEEAFNPGVLDPDVVPLCAALAAREHGDARRALDLLRVAGEI
AERRREERVRREHVYSARAEIERDRVSEVVRTLPLHAKLVLLSIMMLEDG
GRPASTGEIYERYKELTSTLGLEHVTLRRVSGIISELDMLGIVKSRVVSR
GRYGKTREVSLDADRLAVENALSEDPFVARLL

3D structure

• PDB: 2v1u Structural Basis of DNA Replication Origin Recognition by an Orc Protein.
• Chain: A
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	F121 T122 G123 R132 T323 G324 R345 S348 R369 Y370 G371 K372 T373 R374	F109 T110 G111 R120 T306 G307 R328 S331 R352 Y353 G354 K355 T356 R357
BS02	dna	A	T103 Y105 R106 L124 V342 T343 R346 S366 G368 R369 G371 K372	T91 Y93 R94 L112 V325 T326 R329 S349 G351 R352 G354 K355
BS03	ADP	A	L33 P34 T67 G68 K69 T70 A71 Y213 I221 R225 R255 L258	L21 P22 T55 G56 K57 T58 A59 Y196 I204 R208 R238 L241

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003688 DNA replication origin binding
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0006260 DNA replication

External links

• PDB: RCSB:2v1u, PDBe:2v1u, PDBj:2v1u
• PDBsum: 2v1u
• PubMed: 17761880
• UniProt: Q9YEV6|CDC61_AERPE ORC1-type DNA replication protein 1 (Gene Name=orc1)