Structure of PDB 2uzh Chain A

Receptor sequence
>2uzhA (length=153) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
LPRVGLGTDVHPIEAGRPCRLLCLEFDDADGCASDGDVAAHALCDALLSA
AGLGDLGTIFGTDRPQWRGASGADMIRHVRGLVENAGFVIGNATVQVIGN
RPKVGPRREEAQQVLSELVGAPVSVSATTTDGLGLTGRGEGLAAIATALV
AAE
3D structure
PDB2uzh The Structure of Mycobacteria 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase, an Essential Enzyme, Provides a Platform for Drug Discovery.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.6.1.12: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D11 H13 H45 D9 H11 H41
BS02 CDP A G103 N104 P106 K107 V108 A131 T132 T133 G99 N100 P102 K103 V104 A127 T128 T129
BS03 IPE A G138 R142 G134 R138
BS04 CDP A D59 G61 D55 G57
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008685 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0016114 terpenoid biosynthetic process
GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2uzh, PDBe:2uzh, PDBj:2uzh
PDBsum2uzh
PubMed17956607
UniProtA0R559

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