Structure of PDB 2uyq Chain A

Receptor sequence
>2uyqA (length=274) Species: 1769 (Mycobacterium leprae) [Search protein sequence]
VGTTAVMVAAARAAETDRPDALIRDPYAKLLVTNTGAGALWEAMDAEAAA
MVEHMRSYQAVRTNFFDTYFNNAVIDGIRQFVILASGLDSRAYRLDWPTG
TTVYEIDQPKVLAYKSTTLAEHGVTPTADRREVPIDLRQDWPPALRSAGF
DPSARTAWLAEGLLMYLPATAQDGLFTEIGGLSAVGSRIAVETSPLHGDE
WREQMQLRFRRVSDALIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVG
RWGDGVPMADDKDAFAEFVTAHRL
3D structure
PDB2uyq The Crystal Structure of M. Leprae Ml2640C Defines a Large Family of Putative S-Adenosylmethionine- Dependent Methyltransferases in Mycobacteria.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM A A110 D132 D161 L162 R163 A85 D107 D136 L137 R138 MOAD: Kd=2.1uM
PDBbind-CN: -logKd/Ki=5.68,Kd=2.1uM
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2uyq, PDBe:2uyq, PDBj:2uyq
PDBsum2uyq
PubMed17660248
UniProtQ9CCZ4|Y2640_MYCLE Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 (Gene Name=ML2640)

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