Structure of PDB 2uy4 Chain A

Receptor sequence
>2uy4A (length=283) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
TNIAVYWGQNSAGTQESLATYCESSDADIFLLSFLNQFPTLGLNFANACS
DTFSDGLLHCTQIAEDIETCQSLGKKVLLSLGGASGSYLFSDDSQAETFA
QTLWDTFGEGTGASERPFDSAVVDGFDFDIENNNEVGYSALATKLRTLFA
EGTKQYYLSAAPQCPYPDASVGDLLENADIDFAFIQFYNNYCSVSGQFNW
DTWLTYAQTVSPNKNIKLFLGLPGSASAAGSGYISDTSLLESTIADIASS
SSFGGIALWDASQAFSNELGEPYVEILKNLLTS
3D structure
PDB2uy4 Structure of Saccharomyces Cerevisiae Chitinase 1 and Screening-Based Discovery of Potent Inhibitors.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.14: chitinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AZM A F60 A110 D155 Q212 Y214 W285 L307 S310 F34 A84 D129 Q186 Y188 W259 L280 S283 MOAD: Ki=21uM
PDBbind-CN: -logKd/Ki=4.68,Ki=21uM
BindingDB: Ki=21000nM
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2uy4, PDBe:2uy4, PDBj:2uy4
PDBsum2uy4
PubMed17524989
UniProtP29029|CHIT_YEAST Endochitinase (Gene Name=CTS1)

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