Structure of PDB 2uxq Chain A

Receptor sequence
>2uxqA (length=402) Species: 84980 (Desulfotalea psychrophila) [Search protein sequence]
MKIQMKTPLVELDGDEMTRVLWPLIKDKLLLPFIDLQTEYYDLGIEERDR
TNDQITIDAAEAIKKYGVGVKNATITPNQDRVEEYGLKEQWKSPNATVRA
MLDGTVFRKPIMVKNIKPSVRSWQKPIVVGRHAYGDFYKNAEIFAEAGGK
LEIVVTDKNGKETRQTIMEVDEPAIVQGIHNTVASIGHFARACFEYSLDQ
KIDCWFATKDTISKQYDQRFKIIFEEIFAQEYKEKFAAAGIEYFYTLIDD
VVARMMKTEGGMLWACKNYDGDVMSDMVASAFGSLAMMSSVLVSPYGYFE
YEAAHGTVQRHYYQHLKGERTSTNPVALIYAWTGALRKRGELDGTPDLCA
FCDSLEAITIECIESGYMTGDLARICEPAAIKVLDSIEFIDELGKRLQQL
NK
3D structure
PDB2uxq Structural and Functional Properties of Isocitrate Dehydrogenase from the Psychrophilic Bacterium Desulfotalea Psychrophila Reveal a Cold -Active Enzyme with an Unusual High Thermal
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.42: isocitrate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D272 D276 D272 D276
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2uxq, PDBe:2uxq, PDBj:2uxq
PDBsum2uxq
PubMed17632124
UniProtQ6AQ66

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