Structure of PDB 2uw2 Chain A

Receptor sequence
>2uw2A (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
GVEDEPLLRENPIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESL
KPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAME
NIHSEMYSLLIDTYIKDPKEREFLMPCVKKKADWALRWIGDKEATYGERV
VAFAAVEGIFFSGSFASIFWLKKRGPMPGLTFSNELISRDEGLHCDFACL
MFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIE
FVADRLMLELGFSKVFRVENPFDFM
3D structure
PDB2uw2 Crystal Structure of Human Ribonucleotide Reductase Subunit R2
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y176
Catalytic site (residue number reindexed from 1) Y107
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A E169 E232 E266 H269 E100 E157 E191 H194
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
Biological Process
GO:0009263 deoxyribonucleotide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2uw2, PDBe:2uw2, PDBj:2uw2
PDBsum2uw2
PubMed
UniProtP31350|RIR2_HUMAN Ribonucleoside-diphosphate reductase subunit M2 (Gene Name=RRM2)

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