Structure of PDB 2tgd Chain A

Receptor sequence
>2tgdA (length=222) Species: 9913 (Bos taurus) [Search protein sequence]
VGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLG
EDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVA
SISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSA
YPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKN
KPGVYTKVCNYVSWIKQTIASN
3D structure
PDB2tgd Mechanisms of Zymogen Activation
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H39 D83 Q173 G174 D175 S176 G177
Enzyme Commision number 3.4.21.4: trypsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E70 N72 V75 V76 E77 E80 E51 N53 V56 V57 E58 E61
BS02 DFP A F41 H57 G193 S195 F23 H39 G174 S176
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
GO:0097655 serpin family protein binding
Biological Process
GO:0006508 proteolysis
GO:0007586 digestion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0097180 serine protease inhibitor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2tgd, PDBe:2tgd, PDBj:2tgd
PDBsum2tgd
PubMed
UniProtP00760|TRY1_BOVIN Serine protease 1 (Gene Name=PRSS1)

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