Structure of PDB 2tct Chain A

Receptor sequence
>2tctA (length=198) Species: 562 (Escherichia coli) [Search protein sequence]
ARLNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRAL
LDALAVEILARHHDYSLPAAGESWQSFLRNNAMSFRRALLRYRDGAKVHL
GTRPDEKQYDTVETQLRFMTENGFSLRDGLYAISAVSHFTLGAVLEQQEH
TAALNLPPLLREALQIMDSDDGEQAFLHGLESLIRGFEVQLTALLQIV
3D structure
PDB2tct The complex formed between Tet repressor and tetracycline-Mg2+ reveals mechanism of antibiotic resistance.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CTC A H64 N82 F86 H100 R104 P105 V113 Q116 I134 S138 H63 N81 F85 H99 R103 P104 V112 Q115 I133 S137 MOAD: Ka~10000000M^-1
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:2tct, PDBe:2tct, PDBj:2tct
PDBsum2tct
PubMed7707374
UniProtP0ACT4|TETR4_ECOLX Tetracycline repressor protein class D (Gene Name=tetR)

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