Structure of PDB 2rjq Chain A

Receptor sequence
>2rjqA (length=292) Species: 9606 (Homo sapiens) [Search protein sequence]
SRARQVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRL
AVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAI
LFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIG
HLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEF
LDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGMDV
CARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVD
3D structure
PDB2rjq Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H410 H414 H420 H147 H151 H157
BS02 CA A E270 D360 C471 D474 E7 D97 C208 D211
BS03 CA A D369 L370 C376 T378 E398 D106 L107 C113 T115 E135
BS04 BAT A D377 T378 L379 G380 M381 H410 E411 H414 H420 S441 I442 D114 T115 L116 G117 M118 H147 E148 H151 H157 S178 I179
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2rjq, PDBe:2rjq, PDBj:2rjq
PDBsum2rjq
PubMed18042673
UniProtQ9UNA0|ATS5_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 5 (Gene Name=ADAMTS5)

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